As a Scientist / Senior Scientist in the Translational Unit within RII RU, you will play a critical role in bridging preclinical target, asset validation, and early clinical proof-of-concept studies by designing and performing translational assays in human cells, tissues, and biofluids.
This is a lab-based position with an anticipated 4-5 days per week on-site presence at the GSK-Upper Providence (USA) location.
Key responsibilities include:
Work closely with colleagues in the Translational Unit and other RII RU lines (biology, clinical) to design, optimize, and execute preclinical studies to strengthen target-disease hypotheses and validate biomarkers.
Develop and execute technologies related to extracellular vesicles (EVs) such as blood processing, EV isolation, magnetic bead-based immunocapture, nanoparticle analysis, flow cytometry, ELISA/MSD/Quanterix, Western/JESS, TaqMan, and digital PCR.
Identify and progress collaborations with internal and external partners to leverage expertise and resources to support transcriptomics (RNA-Seq) and proteomics (LCMS).
Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project data.
Build translational expertise in technology and disease areas; act as a go-to expert on specific technologies and disease mechanisms.
Work closely with preclinical statistics to ensure robust study design of experiments.
Troubleshoot assays and, when necessary, develop alternative approaches.
Stay up to date with the latest scientific literature and emerging technologies relevant to translational research.
Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner.
Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.
Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research.
Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization.
Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
MS with 2+ years or BS with 4+ years relevant work experience in molecular & cellular biology or related field.
Experience in any of the following technical capabilities: bioassay development and analysis (ELISA/MSD/Quanterix), cell culture, flow cytometry, quantitative PCR, analytic methods, RNA sequencing, extracellular vesicles, and emerging technologies.
Experience in scientific innovation demonstrated through contributions to drug discovery projects, publications, conferences, reports, technical documents, or patents.
Preferred Qualifications:
If you have the following characteristics, it would be a plus:
Excellent problem-solving skills and ability to critically analyze scientific data.
Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.
Proven ability to balance priorities across multiple objectives while maintaining attention to detail and high-performance standards.
Ability to work independently as well as collaboratively in a team-oriented environment.
Experience in RII RU relevant disease mechanisms and pathways, preferably in hepatology (Steatotic Liver Disease), and the ability to apply this knowledge to translational research and biomarker development.
Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.
Experience with bioinformatics tools for the interpretation of large-scale datasets.
Familiarity with the design and execution of biomarker-driven clinical trials and the development of companion diagnostics.
Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development.
GSK-LI
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
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